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Science. 1997 Jan 17;275(5298):400-2.

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases.

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  • 1European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany.


The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.

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