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    Pathologe. 1996 Sep;17(5):374-9.

    [Comparative DNA cytometric and cytogenetic ploidy determination of chondrosarcoma and osteosarcoma].

    [Article in German]
    Werner M, Rieck J, Heintz A, Pösl M, Delling G.

    Source

    Abteilung Osteopathologie, Pathologisches Institut, Universität, Hamburg.

    Abstract

    10 chondrosarcomas and 10 osteosarcomas were examined using cytogenetics and DNA-image-cytometry. Cytogenetically 6 of 10 chondrosarcomas and 4 of 10 osteosarcomas showed hyperdiploid tumorcells. By DNA-cytometry in 8 of 10 chondrosarcomas and 9 of 10 osteosarcomas hyperdiploid tumorcells resp. hyperdiploid stemlines were detected. This discrepancy reflects an in-vitro-selection depending on the different entities. In 7 aneuploid clones of chondrosarcomas the chromosomal ploidy was calculated using the relative length of the chromosomes and compared with the DNA-ploidy of the native tumor. There was a close relation between both parameters of nuclear DNA-content. The interpretation of cytogenetic results is improved using a combination of karyotypic and DNA-cytometric examination. This is particularly important for the search for relations between numeric chromosomal aberrations and morphological parameters (grading).

    PMID:
    8992480
    [PubMed - indexed for MEDLINE]

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