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Immunol Today. 1996 May;17(5):217-24.

Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells.

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  • 1Cancer Research Institute, University of California San Francisco 94143-0128, USA.


Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.

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