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Presse Med. 1996 Nov 30;25(37):1839-45.

[Hyperlipidemia in pregnancy].

[Article in French]

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  • 1Service d'Endocrinologie Métabolisme, Hôpital de la Pitié, Paris.


Hyperlipidemia is one of the most striking modification of biological parameters occurring during normal pregnancy. Hypertriglyceridemia is the most prominent feature, with a less dramatic increase of total cholesterol levels. Besides these quantitative changes, most lipoproteins undergo qualitative modification throughout pregnancy such as triglyceride enrichment of the particles. Kinetics and magnitude of plasma lipids changes have been well recognized, but the mechanisms, metabolic fate and impact on the pathogenesis of cardiovascular disease are not totally unravelled. The primary modulators are estrogens, insulin and lipoprotein lipase. Hyperlipidemia is a result of the metabolic adaptation of the maternal organism to pregnancy allowing to save glucose and energy for the fetus, reversible within a few weeks in postpartum. However some have suggested a trend toward an increased risk for coronary disease after multiple pregnancies. In case of preexisting hyperlipidemia, whether familial or not-primary or secondary, pregnancy presents an additional challenge. Except from exceptional complications, dietary counselling will be the only treatment, under a close follow-up.

[PubMed - indexed for MEDLINE]
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