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Crit Care Med. 1997 Jan;25(1):106-10.

Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males.

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  • 1Department of Surgery, Michigan State University, East Lansing, USA.

Abstract

OBJECTIVES:

To determine: a) whether the cell-mediated immune response during sepsis differs in females vs. males; and b) whether the survival rate in females is different than in males after a septic insult.

DESIGN:

A prospective, randomized animal study.

SETTING:

University research laboratory.

SUBJECTS:

Male and female proestrus C3H/HeN mice.

INTERVENTIONS:

After anesthesia, male and proestrus female mice underwent cecal ligation puncture to induce sepsis. The mice were killed at 24 hrs after the onset of sepsis.

MEASUREMENTS AND MAIN RESULTS:

Splenocyte proliferation, as well as splenocyte interleukin (IL)-2 and IL-3 release, was determined by bioassay. In additional studies, survival rate after septic challenge was measured over 10 days. Splenocyte proliferative capacity and splenocyte IL-2 and IL-3 release were markedly decreased in male, but not in female, septic mice. Furthermore, the survival rate of septic female proestrus mice was significantly higher than in comparable male mice.

CONCLUSIONS:

These results support the concept that the immune response of females differs from males, and that females are immunologically better positioned to meet the challenge of sepsis.

PMID:
8989185
[PubMed - indexed for MEDLINE]
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