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Biosci Biotechnol Biochem. 1996 Nov;60(11):1893-5.

Inhibitory effect of arphamenine A on intestinal dipeptide transport.

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  • 1Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.

Abstract

Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.

PMID:
8987870
[PubMed - indexed for MEDLINE]
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