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Trends Biochem Sci. 1996 Nov;21(11):438-41.

Evidence for a Ras/Ral signaling cascade.

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  • 1Department of Biochemistry, Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.


It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

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