A retrospective review of 24 consecutive patients with Parkinson's disease who underwent 33 primary cemented condylar total knee arthroplasties was performed. The average follow-up period was 33 months, with a minimum follow-up period of 2 years. The pain score improved from 34 points before surgery to 89 points at the latest follow-up examination. The functional score improved from 42 points before surgery to 68 points at the latest follow-up examination. In patients whose Parkinson's disease progressed, the latest functional score was 49.5 points, significantly lower than the scores of those patients who did not progress. The results show that total knee arthroplasty is successful in patients with Parkinson's disease. Unfortunately in some patients. Parkinson's disease progresses and functional results decrease, but the benefit of pain relief persists.