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    Gen Pharmacol. 1996 Oct;27(7):1179-85.

    Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli.

    Usune S, Furukawa T.

    Source

    Research Laboratory of Biodynamics, School of Medicine, Fukuoka University, Japan.

    Abstract

    1. The effects of angiotensin (Ang) II receptor antagonist, SC-52458, on peak and plateau components of Ang II-induced contraction were evaluated in the guinea-pig taenia coli. 2. SC-52458 suppressed both the components of and increases in cytoplasmic Ca2+ concentrations, [Ca2+]i, coupled with the contraction by Ang II; tetrodotoxin and atropine did not affect the contractions. 3. SC-52458 inhibited a plateau component of the contraction induced by K(+)-depolarization to some extent, without affecting a peak component. 4. SC-52458 suppressed both the contraction and increase of [Ca2+]i by antagonizing AT1 receptors in the smooth muscle.

    PMID:
    8981065
    [PubMed - indexed for MEDLINE]

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