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Cytokine Growth Factor Rev. 1996 Oct;7(3):241-8.

The immunology of Eta-1/osteopontin.

Author information

  • 1Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.

PMID:
8971479
[PubMed - indexed for MEDLINE]
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