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1: Tex Heart Inst J. 1996;23(4):301-4.Click here to read Links

Ketanserin in the treatment of protamine-induced pulmonary hypertension.

van der Starre PJ, Solinas C.

Department of Cardiothoracic Anesthesiology and Intensive Care Hospital De Weezenlanden, Netherlands.

The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement. The potential role of serotonin in the development of this serious complication is discussed.

PMID: 8969033 [PubMed - indexed for MEDLINE]

PMCID: PMC325377