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1: Science. 1996 Dec 20;274(5295):2089-91.Click here to read Links

Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.

Holmes TC, Fadool DA, Ren R, Levitan IB.

Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.

The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.

PMID: 8953041 [PubMed - indexed for MEDLINE]

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