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J Vasc Interv Radiol. 1996 Nov-Dec;7(6):853-8.

Local delivery of heparin with balloon angioplasty: results of a prospective randomized trial.

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  • 1Department of Radiology, Legacy Good Samaritan Hospital and Medical Center, Portland, OR 97210, USA.

Abstract

PURPOSE:

To evaluate the effectiveness of local delivery of heparin via hydrogel-coated balloons in the treatment of vascular stenoses associated with hemodialysis access.

MATERIALS AND METHODS:

This was a randomized, prospective trial comparing treatment with hydrogel-coated balloon catheters delivered with heparin coating (n = 33) and without (n = 26). All patients were undergoing hemodialysis, and all stenoses involved the venous anastomosis of a dialysis graft or a native vein. The heparin-treated balloons were soaked in concentrated heparin and delivered in a protected manner to help prevent washout of heparin.

RESULTS:

The mean primary patencies were 143 days with heparin treatment and 214 days without heparin (P = .174). The mean assisted primary patencies were 165 days with heparin and 194 days without (P = .315). The mean secondary patencies were 351 days with heparin and 384 without (P = .81).

CONCLUSION:

In this population with this technique, the treatment outcome of venous outflow stenosis in patients with dialysis grafts is not improved with local delivery of heparin.

PMID:
8951752
[PubMed - indexed for MEDLINE]
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