Abstract
We recently completed a map of the human immunoglobulin lambda (IGL) locus on chromosome 22q11.2 and showed that the V lambda genes are arranged in three distinct clusters, each containing members of different V lambda families. We have now sequenced each of these V lambda genes and determined which are functional by comparison with the expressed repertoire. Our analysis indicates that there are approximately 30 functional V lambda genes, depending on the haplotype, that belong to ten V lambda families (five V lambda 1, five V lambda 2, eight V lambda 3, three V lambda 4, three V lambda 5, one V lambda 6, two V lambda 7, one V lambda 8, one V lambda 9 and one V lambda 10). V lambda genes related to the major human V lambda families (V lambda 1, V lambda 2 and V lambda 3) predominate in species that express mainly lambda light chains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA
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Evolution, Molecular
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Germ Cells
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Humans
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Immunoglobulin Variable Region / classification
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Immunoglobulin Variable Region / genetics*
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Immunoglobulin lambda-Chains / classification
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Immunoglobulin lambda-Chains / genetics*
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Molecular Sequence Data
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Phylogeny
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
Substances
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Immunoglobulin Variable Region
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Immunoglobulin lambda-Chains
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DNA
Associated data
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GENBANK/X97462
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GENBANK/X97463
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GENBANK/X97464
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GENBANK/X97465
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GENBANK/X97466
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GENBANK/X97467
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GENBANK/X97468
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GENBANK/X97469
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GENBANK/X97470
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GENBANK/X97471
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GENBANK/X97472
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GENBANK/X97473
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GENBANK/X97474
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GENBANK/Z73641
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GENBANK/Z73642
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GENBANK/Z73649
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GENBANK/Z73650
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GENBANK/Z73657