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Br J Surg. 1997 Feb;84(2):279.
Aetiology and treatment of anal fissure.
Department of Surgery, University Hospital, Nottingham, UK.
Anal fissure is a common problem that causes significant morbidity in a young and otherwise healthy population. Treatment has remained largely unchanged for over 150 years and the pathogenesis of this condition is not yet fully explained. Acute fissure should be treated conservatively with dietary modification. Chronic fissures do not respond to conservative treatment. The current recommended surgical treatment for chronic fissure is lateral internal sphincterotomy. However, there is a disturbance of continence in a sizeable proportion of those undergoing this procedure. As yet there is no proven non-surgical treatment for chronic fissure. Although local injection of botulinum toxin and the topical application of nitrates show early promise, further controlled trials are needed.
PMID: 8944447 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Botulinum toxin treatment for anal fissure.
Radwan MM, Ramdan K, Abu-Azab I, Abu-Zidan FM.
Afr Health Sci. 2007 Mar; 7(1):14-7.
[Afr Health Sci. 2007]
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Botulinum toxin injection versus lateral internal sphincterotomy in the treatment of chronic anal fissure: a non-randomized controlled trial.
Giral A, Memisoglu K, Gültekin Y, Imeryüz N, Kalayci C, Ulusoy NB, Tözün N.
BMC Gastroenterol. 2004 Mar 22; 4:7. Epub 2004 Mar 22.
[BMC Gastroenterol. 2004]
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ReviewNeuromyogenic properties of the internal anal sphincter: therapeutic rationale for anal fissures.
Bhardwaj R, Vaizey CJ, Boulos PB, Hoyle CH.
Gut. 2000 Jun; 46(6):861-8.
[Gut. 2000]
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