Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 1996 Nov;175(5):1365-70.

Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications.

Author information

  • 1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.

Abstract

The cause of preeclampsia remains elusive in spite of many attempts to understand its biologic characteristics and to characterize its predictors. We suggest that there are distinct origins of preeclampsia, each with its own pathologic characteristics and natural history. One genesis is the result of reduced placental perfusion, which we will call placental, and another results from maternal disorders preexisting (but sometimes not evident before) pregnancy. These preexisting maternal disorders comprise predisposing factors for cardiovascular disease such as hypertension, renal disease, overweight, and diabetes. A critical review of the epidemiologic and pathologic literature is presented, which supports the hypothesis that preeclampsia is the result of heterogeneous causes. The implications of this hypothesis are discussed, particularly its impact on the development of rules to predict the occurrence of preeclampsia.

Comment in

PMID:
8942516
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk