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1: Cytogenet Cell Genet. 1996;74(3):225-6.Links

The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis.

Still IH, Cowell J.

Department of Neurosciences NC30, Cleveland Clinic Foundation, Ohio 44195, USA.

We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.1-->q22. Furthermore, we have shown that two YACs, known to contain the closest marker linked to neuronal ceroidlipofuscinosis (CLN5), also contains the Brn-3a gene. As one of these YACs is only 320 kb long, this localises POU4F1 within the critical region defining the CLN5 locus, and raises the possibility that POU4F1 is a candidate gene for CLN5.

PMID: 8941380 [PubMed - indexed for MEDLINE]