J Infect Dis. 1996 Dec;174(6):1207-11.

After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group.

Cooper ER, Nugent RP, Diaz C, Pitt J, Hanson C, Kalish LA, Mendez H, Zorrilla C, Hershow R, Moye J, Smeriglio V, Fowler MG.

Source

Boston City Hospital/Boston University School of Medicine, Massachusetts 02118, USA.

Abstract

To determine the impact of the AIDS Clinical Trials Group (ACTG) Protocol 076 results on the subsequent use of zidovudine during pregnancy and the transmission rate of human immunodeficiency virus (HIV) in a cohort of mother-infant pairs (Women and Infants Transmission Study), a retrospective analysis was done. Transmission rates were calculated by simple proportion for infants with at least 6 months of follow-up, stratified by date of birth (n = 453 born on or before 1 March 1994; n = 103 born after 1 March 1994). Transmission rates decreased from 19% to 8% (P = .005, Fisher's exact test). Zidovudine use increased during pregnancy (22% vs. 89%) and in newborns (1% vs. 79%). Both cohorts were similar with respect to maternal immunosuppression, mode of delivery, and demographics. In summary, in a perinatal HIV observational study, the release of results of ACTG Protocol 076 was associated with an increase in zidovudine use during pregnancy and a concomitant decline in HIV transmission from mothers to infants.

PMID:: 8940210; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

ZIDOVUDINE - HSDB

Supplemental Content

Related citations

Reduction in the risk of vertical transmission of HIV-1 associated with treatment of pregnant women with orally administered zidovudine alone. [J Acquir Immune Defic Syndr Hum Retrovirol....]
Reduction in the risk of vertical transmission of HIV-1 associated with treatment of pregnant women with orally administered zidovudine alone.
Simpson BJ, Shapiro ED, Andiman WA. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Feb 1; 14(2):145-52.
HIV infection and zidovudine use in childbearing women. [Pediatrics. 2004]
HIV infection and zidovudine use in childbearing women.
Sia J, Paul S, Martin RM, Cross H. Pediatrics. 2004 Dec; 114(6):e707-12. Epub 2004 Nov 15.
Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. [JAMA. 1999]
Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams.
Culnane M, Fowler M, Lee SS, McSherry G, Brady M, O'Donnell K, Mofenson L, Gortmaker SL, Shapiro DE, Scott G, et al. JAMA. 1999 Jan 13; 281(2):151-7.
Review Reducing the risk of perinatal HIV-1 transmission with zidovudine: results and implications of AIDS Clinical Trials Group protocol 076. [Acta Paediatr Suppl. 1997]
Review Reducing the risk of perinatal HIV-1 transmission with zidovudine: results and implications of AIDS Clinical Trials Group protocol 076.
Mofenson LM. Acta Paediatr Suppl. 1997 Jun; 421:89-96.
Review Interventions for preventing late postnatal mother-to-child transmission of HIV. [Cochrane Database Syst Rev. 2009]
Review Interventions for preventing late postnatal mother-to-child transmission of HIV.
Horvath T, Madi BC, Iuppa IM, Kennedy GE, Rutherford G, Read JS. Cochrane Database Syst Rev. 2009 Jan 21; (1):CD006734. Epub 2009 Jan 21.

See reviews... See all...

Cited by 4 PubMed Central articles

Human immunodeficiency virus-1 and preconception care. [Matern Child Health J. 2006]
Human immunodeficiency virus-1 and preconception care.
Lampe MA. Matern Child Health J. 2006 Sep; 10(5 Suppl):S193-5. Epub 2006 Jul 11.
Genetic analysis of simian immunodeficiency virus expressed in milk and selectively transmitted through breastfeeding. [J Virol. 2006]
Genetic analysis of simian immunodeficiency virus expressed in milk and selectively transmitted through breastfeeding.
Rychert J, Lacour N, Amedee AM. J Virol. 2006 Apr; 80(8):3721-31.
Review British HIV Association guidelines for prescribing antiretroviral therapy in pregnancy (1998). [Sex Transm Infect. 1999]
Review British HIV Association guidelines for prescribing antiretroviral therapy in pregnancy (1998).
Taylor GP, Lyall EG, Mercey D, Smith R, Chester T, Newell ML, Tudor-Williams G. Sex Transm Infect. 1999 Apr; 75(2):90-7.

See all...

Chemical compound information

Zidovudine

MW: 267.24 g/mol

MF: C₁₀H₁₃N₅O₄

See 904 citations for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

After AIDS clinical trial 076: the changing pattern of zidovudine use during pre...
After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group.
J Infect Dis. 1996 Dec ;174(6):1207-11.

PubMed
Introduction to cerebral perfusion pressure management.
Introduction to cerebral perfusion pressure management.
Neurosurg Clin N Am. 1995 Oct ;6(4):761-73.

PubMed
Ear infection: a retrospective study examining improvement from chiropractic car...
Ear infection: a retrospective study examining improvement from chiropractic care and analyzing for influencing factors.
J Manipulative Physiol Ther. 1996 Mar-Apr ;19(3):169-77.

PubMed
Hazards of routine endotracheal suction in the neonatal unit.
Hazards of routine endotracheal suction in the neonatal unit.
Lancet. 1989 Jun 24 ;1(8652):1444-5.

PubMed
Risk factors for the syndrome of ventricular enlargement with gait apraxia (idio...
Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic normal pressure hydrocephalus): a case-control study.
J Neurol Neurosurg Psychiatry. 1989 Jul ;52(7):847-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 4 PubMed Central articles

Chemical compound information

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information