Curr Opin Genet Dev. 1996 Oct;6(5):618-23.

Hookworm: developmental biology of the infectious process.

Source

Medical Helminthology Laboratory, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. hawdonjm@maspo1.mas.yale.edu

Abstract

Hookworms cause severe anemia and malnutrition in developing countries of the tropics, with an estimated one billion people infected worldwide. An in vitro system that models the early events of infection has provided new information about the linkage between the infectious process and the parasite's developmental biology. The cloning and expression of Ancylostoma secreted protein, ASP 1 - a secreted molecule associated with these developmental processes - is an example of how this system allows us to dissect the infectious process at the molecular level.

PMID:: 8939719; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Molecular approaches to vaccinating against hookworm disease. [Pediatr Res. 1996]
Review Molecular approaches to vaccinating against hookworm disease.
Hotez PJ, Hawdon JM, Cappello M, Jones BF, Ghosh K, Volvovitz F, Xiao SH. Pediatr Res. 1996 Oct; 40(4):515-21.
Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae. [J Biol Chem. 1996]
Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae.
Hawdon JM, Jones BF, Hoffman DR, Hotez PJ. J Biol Chem. 1996 Mar 22; 271(12):6672-8.
Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum. [Mol Biochem Parasitol. 1999]
Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum.
Hawdon JM, Narasimhan S, Hotez PJ. Mol Biochem Parasitol. 1999 Apr 30; 99(2):149-65.
Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum. [J Infect Dis. 2004]
Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum.
Goud GN, Zhan B, Ghosh K, Loukas A, Hawdon J, Dobardzic A, Deumic V, Liu S, Dobardzic R, Zook BC, et al. J Infect Dis. 2004 Mar 1; 189(5):919-29. Epub 2004 Feb 6.
Review Immunobiology of hookworm infection. [FEMS Immunol Med Microbiol. 2005]
Review Immunobiology of hookworm infection.
Loukas A, Constant SL, Bethony JM. FEMS Immunol Med Microbiol. 2005 Feb 1; 43(2):115-24.

See reviews... See all...

Cited by 11 PubMed Central articles

RNA and protein synthesis is required for Ancylostoma caninum larval activation. [Vet Parasitol. 2011]
RNA and protein synthesis is required for Ancylostoma caninum larval activation.
Dryanovski DI, Dowling C, Gelmedin V, Hawdon JM. Vet Parasitol. 2011 Jun 30; 179(1-3):137-43. Epub 2011 Feb 26.
Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation. [Int J Parasitol. 2011]
Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation.
Krepp J, Gelmedin V, Hawdon JM. Int J Parasitol. 2011 Apr; 41(5):533-43. Epub 2010 Dec 21.
Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1. [Acta Crystallogr Sect F Struct...]
Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1.
Bonafé N, Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1; 66(Pt 11):1487-9. Epub 2010 Oct 28.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hookworm: developmental biology of the infectious process.
Hookworm: developmental biology of the infectious process.
Curr Opin Genet Dev. 1996 Oct ;6(5):618-23.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Hookworm: developmental biology of the infectious process.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information