J Bone Joint Surg Br. 1977 Aug;59(3):279-86.

Benign osteoblastoma as a cause of osteomalacia. A report of two cases.

Yoshikawa S, Nakamura T, Takagi M, Imamura T, Okano K, Sasaki S.

Abstract

Two patients, a Japanese man and woman both aged eighteen, developed symptoms and signs of osteomalacia over a period of five years. Each of them had a benign osteoblastoma, one in the right fourth metacarpal and the other in the uppermost third of the right humerus. Resection of the tumours without any treatment by vitamin D resulted in rapid cure of the osteomalacia. Attempts to prove a phosphaturic humoral substance or vitamin D antagonist in the osteoblastoma of the humerus were unsuccessful, probably due to prompt excretion from the tumour cells.

PMID:: 893505; [PubMed - indexed for MEDLINE]

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