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Nature. 1996 Nov 28;384(6607):327-33.

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

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  • 1Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA.

Abstract

The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.

PMID:
8934515
[PubMed - indexed for MEDLINE]
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