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Pharm Res. 1996 Feb;13(2):296-300.

Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide.

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  • 1Department of Pharmaceutics, University of Florida, Gainesville 32610, USA.

Abstract

PURPOSE:

The antinociceptive and immunosuppressive effects of codeine and codeine 6-glucuronide were determined in rats after intracerebroventricular administration.

METHODS:

Codeine 6-glucuronide was synthesized using a modification of the Koenigs-Knorr reaction. A lipophilic intermediate formed during synthesis, methyl [codein-6-yl-2,3,4-tri-O-acetyl-beta-D-glucopyranosid] uronate, was also tested. Morphine was used as a positive control to compare antinociceptive potencies of these compounds.

RESULTS:

All compounds tested produced significant analgesic responses, as assessed by the tail flick model. Additionally, codeine 6-glucuronide showed significantly less immunosuppressive effects than codeine in vitro.

CONCLUSIONS:

We conclude that codeine 6-glucuronide and related compounds may have clinical benefit in the treatment of pain in immune compromised patients.

PMID:
8932452
[PubMed - indexed for MEDLINE]
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