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1: Palliat Med. 1996 Oct;10(4):313-7.Links

Dextromoramide pharmacokinetics following sublingual administration.

Jones TE, Morris RG, Saccoia NC, Thorne D.

Department of Pharmacy, Queen Elizabeth Hospital, Woodville, South Australia.

The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia. The use of the standard 5 mg tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three and substantial variability in clearance. The study concluded that the standard tablet formulation cannot be recommended for sublingual use where reliable, rapid onset analgesia is required.

PMID: 8931067 [PubMed - indexed for MEDLINE]