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Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.

Pharmacokinetics of thiamine derivatives especially of benfotiamine.

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  • 1Wuppertal, Germany.

Abstract

Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only after benfotiamine was given. Due to its excellent pharmacokinetic profile benfotiamine should be preferred in treatment of relevant indications.

PMID:
8929745
[PubMed - indexed for MEDLINE]
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