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Rheum Dis Clin North Am. 1996 Nov;22(4):765-81.

Raynaud's phenomenon.

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  • 1Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

Raynaud's phenomenon is a common clinical problem occurring in 3% to 5% of the general population. The first symptom of scleroderma is often Raynaud's phenomenon, which is associated with a diffuse small vessel vasculopathy and ischemia and reperfusion injury to skin and other organs targeted in this disease. Current studies support the concept that Raynaud's phenomenon is secondary to a local defect in the regulation of regional blood flow. New evidence demonstrates that there is a profound sensitivity to alpha 2-adrenoceptors mediated vasoconstriction in scleroderma vessels. Traditional treatment of Raynaud's phenomenon is cold avoidance and the use of vasodilators. Oral prostaglandins have shown promise as therapeutic agents.

PMID:
8923595
[PubMed - indexed for MEDLINE]
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