J Rheumatol. 1996 Nov;23(11):1988-90.

Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma.

Rosenstein ED, Kramer N, Leitner SP, Michaelson RA.

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Department of Medicine, St. Barnabas Medical Center (SBMC), Livingston, NJ, USA.

Abstract

Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy. Within two months of termination of chemotherapy, all 3 patients developed florid synovitis. Two patients had prior clinical manifestations consistent with rheumatoid arthritis; one patient had no antecedent history of arthritis. We suggest that this presentation may represent exacerbation of mild or subclinical rheumatoid arthritis as a consequence of withdrawal of methotrexate therapy.

PMID:: 8923380; [PubMed - indexed for MEDLINE]

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