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Genomics. 1996 Oct 1;37(1):122-4.

Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.

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  • 1Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, United Kingdom. rroberts@hgmp.mrc.ac.uk


The rat gene Leucine-Rich Primary Response Gene-1 (LRPR1) has been proposed to encode a protein involved in the response of gonadal tissues to follicle-stimulating hormone. We have characterized a human transcript that probably encodes the orthologue of the rat protein, exhibiting 72% identity at the amino acid level. The gene from which the transcript is derived maps to human chromosomal region Xq22 and therefore becomes a potential candidate for human X-linked disorders of gonadal development.

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