Sequence and chromosomal location of a human homol...[Genomics. 1996]

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1: Genomics. 1996 Oct 1;37(1):122-4. Links

Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.

Roberts RG, Kendall E, Vetrie D, Bobrow M.

Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, United Kingdom. rroberts@hgmp.mrc.ac.uk

The rat gene Leucine-Rich Primary Response Gene-1 (LRPR1) has been proposed to encode a protein involved in the response of gonadal tissues to follicle-stimulating hormone. We have characterized a human transcript that probably encodes the orthologue of the rat protein, exhibiting 72% identity at the amino acid level. The gene from which the transcript is derived maps to human chromosomal region Xq22 and therefore becomes a potential candidate for human X-linked disorders of gonadal development.

PMID: 8921378 [PubMed - indexed for MEDLINE]

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