Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum

J Natl Cancer Inst. 1979 Sep;63(3):745-50. doi: 10.1093/jnci/63.3.745.

Abstract

Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / administration & dosage*
  • Cell Transformation, Neoplastic*
  • Clone Cells
  • Embryo, Mammalian
  • RNA, Viral / metabolism
  • RNA-Directed DNA Polymerase / metabolism
  • Rats
  • Retroviridae / enzymology
  • Retroviridae / immunology*
  • Sarcoma Viruses, Murine / metabolism
  • Virus Replication

Substances

  • Antibodies, Viral
  • RNA, Viral
  • RNA-Directed DNA Polymerase