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Environ Health Perspect. 1996 Mar;104(3):298-305.

Estrogenicity of resin-based composites and sealants used in dentistry.

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  • 1Department of Radiology, Dentistry, and Department of Nutrition, School of Pharmacy, University of Granada, Spain.

Abstract

We tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.

PMID:
8919768
[PubMed - indexed for MEDLINE]
PMCID:
PMC1469315
Free PMC Article
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