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Biochimie. 1996;78(6):381-9.

Aminoacyl-tRNA synthetase gene regulation in Bacillus subtilis.

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  • 1UPR 9073, Institut de Biologie Physico-Chimique, Paris, France.


In this review, we summarize progress on the regulation of the aminoacyl-tRNA synthetase genes in Bacillus subtilis. Most of the genes encoding this set of enzymes in B subtilis are members of a large family of Gram-positive genes and operons controlled by a novel antitermination mechanism that uses their cognate uncharged tRNA as the effector. A subset of these genes is, in addition, likely to be controlled at the level of mRNA processing and degradation. We describe the key experiments leading to these conclusions.

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