Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

D N Garboczi; P Ghosh; U Utz; Q R Fan; W E Biddison; D C Wiley

doi:10.1038/384134a0

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

Nature. 1996 Nov 14;384(6605):134-41. doi: 10.1038/384134a0.

Authors

D N Garboczi¹, P Ghosh, U Utz, Q R Fan, W E Biddison, D C Wiley

Affiliation

¹ Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 8906788
DOI: 10.1038/384134a0

Abstract

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

Publication types

Comment
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Crystallography, X-Ray
Gene Products, tax / chemistry*
Gene Products, tax / immunology
HLA-A2 Antigen / chemistry*
HLA-A2 Antigen / immunology
Human T-lymphotropic virus 1 / chemistry
Human T-lymphotropic virus 1 / immunology
Humans
Immune Tolerance
Immunoglobulin Fragments / chemistry
Major Histocompatibility Complex
Models, Molecular
Protein Binding
Protein Conformation
Receptors, Antigen, T-Cell / chemistry*
Receptors, Antigen, T-Cell / immunology
Signal Transduction

Substances

Gene Products, tax
HLA-A2 Antigen
Immunoglobulin Fragments
Receptors, Antigen, T-Cell