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Trends Microbiol. 1996 Oct;4(10):375-82.

Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.

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  • 1Institut für Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg-Universítdt Mainz, Germany.


Some Clostridium species produce ABX-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.

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