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    Cell. 1996 Nov 1;87(3):427-36.

    Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family.

    Montgomery RI, Warner MS, Lum BJ, Spear PG.

    Source

    Northwestern University Medical School, Department of Microbiology-Immunology, Chicago, Illinois 60611, USA.

    Abstract

    We identified and cloned a cellular mediator of herpes simplex virus (HSV) entry. Hamster and swine cells resistant to viral entry became susceptible upon expression of a human cDNA encoding this protein, designated HVEM (for herpesvirus entry mediator). HVEM was shown to mediate the entry of several wild-type HSV strains of both serotypes. Anti-HVEM antibodies and a soluble hybrid protein containing the HVEM ectodomain inhibited HVEM-dependent infection but not virus binding to cells. Mutations in the HSV envelope glycoprotein gD significantly reduced HVEM-mediated entry. The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family.

    PMID:
    8898196
    [PubMed - indexed for MEDLINE]

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