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Science. 1996 Nov 15;274(5290):1109-15.

Patterning the vertebrate neuraxis.

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  • 1Department of Developmental Neurobiology, United Medical and Dental Schools, Guy's Hospital, London SE1 9RT, UK. a.lumsden@umds.ac.uk


Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.

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