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1: Arch Neurol. 1977 Aug;34(8):508-10.Click here to read Links

Bony and vascular anomalies of the head. Their possible relation to anencephaly.

Frens DB, Ziter FA, Bray PF.

This study links a midfacial anomaly in an 8-year-old boy, with underlying bony skull defects and abnormalities of the cerebral vasculature, with an earlier spontaneous miscarriage and the subsequent birth of a frankly anencephalic sibling. We believe that the midfacial and vascular anomalies in the second child could represent a forme fruste of anencephaly, which should alert the physician to monitor subsequent pregnancies for the complete anencephalic phenotype.

PMID: 889486 [PubMed - indexed for MEDLINE]