Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists

J Med Chem. 1996 Oct 25;39(22):4354-7. doi: 10.1021/jm960148m.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Drug Compounding / methods*
  • Humans
  • Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
  • Robotics / methods
  • Solutions
  • Transfection
  • Triazines / chemistry*

Substances

  • Receptors, Corticotropin-Releasing Hormone
  • Solutions
  • Triazines
  • CRF receptor type 1