Dig Dis Sci. 1996 Oct;41(10):2087-94.

n-3 fatty acids only delay early relapse of ulcerative colitis in remission.

Loeschke K, Ueberschaer B, Pietsch A, Gruber E, Ewe K, Wiebecke B, Heldwein W, Lorenz R.

Source

Klinikum Innenstadt, Universität München, Germany.

Abstract

Relapse prevention by dietary n-3 fatty acids (5.1 g/day) was studied in a double-blind, placebo-controlled trial of 64 patients with ulcerative colitis in remission and off steroids. 5-ASA compounds were stopped three months after randomization and clinical disease activity monitored for two years. Macroscopic and histologic activity and extension was assessed by colonoscopy at entry and at exit. Both treatment groups were well matched at start. Nine patients on placebo and eight on n-3 fatty acids stopped taking their medication prematurely. Actuarial relapse-free survival was improved by n-3 fatty acids only during months 2 and 3 (2P < 0.05-0.01), but cumulative relapse rate at two years was similar for those taking placebo (18/33 = 55%) and n-3 fatty acids (18/31 = 58%). There was also no consistent difference in clinical, macroscopic, and histologic disease activity between treatment groups. The n-3 fatty acids temporarily retard, but do not prevent, relapse of ulcerative colitis.

PMID:: 8888725; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Fatty Acids, Omega-3

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis. [Aliment Pharmacol Ther. 2002]
A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis.
Middleton SJ, Naylor S, Woolner J, Hunter JO. Aliment Pharmacol Ther. 2002 Jun; 16(6):1131-5.
Review Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. [Cochrane Database Syst Rev. 2007]
Review Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis.
Turner D, Steinhart AH, Griffiths AM. Cochrane Database Syst Rev. 2007 Jul 18; (3):CD006443. Epub 2007 Jul 18.
Is maintenance therapy always necessary for patients with ulcerative colitis in remission? [Aliment Pharmacol Ther. 1999]
Is maintenance therapy always necessary for patients with ulcerative colitis in remission?
Ardizzone S, Petrillo M, Imbesi V, Cerutti R, Bollani S, Bianchi Porro G. Aliment Pharmacol Ther. 1999 Mar; 13(3):373-9.
Oral and topical 5-aminosalicylic acid (mesalazine) in inducing and maintaining remission in mild-moderate relapse of ulcerative colitis: one-year randomised multicentre trial. [Dig Liver Dis. 2002]
Oral and topical 5-aminosalicylic acid (mesalazine) in inducing and maintaining remission in mild-moderate relapse of ulcerative colitis: one-year randomised multicentre trial.
Paoluzi P, D'Albasio G, Pera A, Bianchi Porro G, Paoluzi OA, Pica R, Cottone M, Miglioli M, Prantera C, Sturniolo G, et al. Dig Liver Dis. 2002 Nov; 34(11):787-93.
Review Lipid treatment of inflammatory bowel disease. [Curr Opin Clin Nutr Metab Care...]
Review Lipid treatment of inflammatory bowel disease.
Endres S, Lorenz R, Loeschke K. Curr Opin Clin Nutr Metab Care. 1999 Mar; 2(2):117-20.

See reviews... See all...

Cited by 1 PubMed Central article

Review The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes. [Clin Exp Immunol. 2005]
Review The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes.
Mills SC, Windsor AC, Knight SC. Clin Exp Immunol. 2005 Nov; 142(2):216-28.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

n-3 fatty acids only delay early relapse of ulcerative colitis in remission.
n-3 fatty acids only delay early relapse of ulcerative colitis in remission.
Dig Dis Sci. 1996 Oct ;41(10):2087-94.

PubMed
Free testosterone concentration in serum: elevation is the hallmark of hirsutism...
Free testosterone concentration in serum: elevation is the hallmark of hirsutism.
Am J Obstet Gynecol. 1977 Aug 15 ;128(8):851-7.

PubMed
Carboxymethylated beta-1,3-glucan inhibits the binding and degradation of acetyl...
Carboxymethylated beta-1,3-glucan inhibits the binding and degradation of acetylated low density lipoproteins in macrophages in vitro and modulates their plasma clearance in vivo.
Cell Biochem Funct. 1996 Sep ;14(3):209-17.

PubMed
Evaluation of the adult patient with diarrhea.
Evaluation of the adult patient with diarrhea.
Prim Care. 1996 Sep ;23(3):629-47.

PubMed
Salmonella typhi infections in the United States, 1967-1972: increasing importan...
Salmonella typhi infections in the United States, 1967-1972: increasing importance of international travelers.
Am J Epidemiol. 1977 Aug ;106(2):160-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: