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Schizophr Res. 1996 Sep 18;21(3):133-9.

Decreased frontal cortical serotonin2A receptors in schizophrenia.

Author information

  • 1Rebecca L. Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia. Bdean@papyrus.mhri.edu.au

Abstract

5HT2A receptors were measured in the frontal cortex from schizophrenic and non-schizophrenic subjects. There was a decrease in the density of 5HT2A receptors in Brodmann's areas 8, 9 and 10 from the schizophrenic subjects. In addition, there was an age-dependent decrease in the density of 5HT2A receptors in Brodmann's areas 9 from the non-schizophrenic subjects, which was absent in the schizophrenic subjects. Available evidence does not suggest that the change in 5HT2A receptors in the schizophrenic subjects was a result of drug treatment before death. These data may indicate that decreased 5HT2A receptors in the frontal cortex are involved in the pathology of schizophrenia.

PMID:
8885041
[PubMed - indexed for MEDLINE]
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