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1: Nature. 1996 Oct 24;383(6602):685-90.Click here to read Links
Comment in:
Nature. 1996 Oct 24;383(6602):666-7.
Nature. 1997 Apr 10;386(6625):564.
Nature. 1997 Mar 20;386(6622):232-4.

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

Collinge J, Sidle KC, Meads J, Ironside J, Hill AF.

Neurogenetics Unit, Department of Biochemistry and Molecular Genetics, Imperial College School of Medicine at St. Mary's, London, UK. j.collinge@ic.ac.uk

Strains of transmissible spongiform encephalopathies are distinguished by differing physicochemical properties of PrPSc, the disease-related isoform of prion protein, which can be maintained on transmission to transgenic mice. 'New variant' Creutzfeldt-Jakob disease (CJD) has strain characteristics distinct from other types of CJD and which resemble those of BSE transmitted to mice, domestic cat and macaque, consistent with BSE being the source of this new disease. Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype.

PMID: 8878476 [PubMed - indexed for MEDLINE]