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Ann Acad Med Singapore. 1996 May;25(3):347-51.

Preliminary experience of infusional brachytherapy using colloidal 32P.

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  • 1Department of Radiological Physics, Cooper Hospital/University Medical Center, Camden, New Jersey 08103, USA.

Abstract

In the past, we have clinically evaluated radiolabelled antibodies in Hodgkin's disease and hepatocellular cancer. Increased tumour pressure, reduced vascularity and poor diffusion has limited significant radiolabelled antibody tumour dose deposition. Using intratumoural infusion of macroaggregated albumin to blockade exiting vasculature followed by colloidal chromic 32Phosphorous, we have been able to achieve 75% to 100% tumour dose deposition by interstitial tumour infusion under computerised tomographic guidance. Phase I studies in a variety of solid tumours indicate extremely high doses may be achieved without toxicity (i.e. non-resectable pancreas 900,000 cGy to 1.7 million cGy) with tumour control and remission. This is a review of those studies and how the technique was applied.

PMID:
8876899
[PubMed - indexed for MEDLINE]
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