Biol Psychiatry. 1996 Sep 1;40(5):382-8.

Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients.

Stoll AL, Sachs GS, Cohen BM, Lafer B, Christensen JD, Renshaw PF.

Source

Psychopharmacology Unit, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Abstract

This study examined choline augmentation of lithium for rapid-cycling bipolar disorder. Choline bitartrate was given openly to 6 consecutive lithium-treated outpatients with rapid-cycling bipolar disorder. Five patients also underwent brain proton magnetic resonance spectroscopy. Five of 6 rapid-cycling patients had a substantial reduction in manic symptoms, and 4 patients had a marked reduction in all mood symptoms during choline therapy. The patients who responded to choline all exhibited a substantial rise in the basal ganglia concentration of choline-containing compounds. Choline was well tolerated in all cases. Choline, in the presence of lithium, was a safe and effective treatment for 4 of 6 rapid-cycling patients in our series. A hypothesis is suggested to explain both lithium refractoriness in patients with bipolar disorder and the action of choline in mania, which involves the interaction between phosphatidylinositol and phosphatidylcholine second-messenger systems.

PMID:: 8874839; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Related citations

Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. [J Psychiatry Neurosci. 1996]
Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder.
Kato T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T. J Psychiatry Neurosci. 1996 Jul; 21(4):248-54.
Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy. [Bipolar Disord. 2003]
Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy.
Lyoo IK, Demopulos CM, Hirashima F, Ahn KH, Renshaw PF. Bipolar Disord. 2003 Aug; 5(4):300-6.
Review [Antipsychotics in bipolar disorders]. [Encephale. 2004]
Review [Antipsychotics in bipolar disorders].
Vacheron-Trystram MN, Braitman A, Cheref S, Auffray L. Encephale. 2004 Sep-Oct; 30(5):417-24.
Lamotrigine combined with divalproex or lithium for bipolar disorder: a case series. [CNS Spectr. 2006]
Lamotrigine combined with divalproex or lithium for bipolar disorder: a case series.
Redmond JR, Jamison KL, Bowden CL. CNS Spectr. 2006 Dec; 11(12):915-8.
Review [Clinical relevance and treatment possibilities of rapid cycling in patients with bipolar disorder]. [Fortschr Neurol Psychiatr. 2001]
Review [Clinical relevance and treatment possibilities of rapid cycling in patients with bipolar disorder].
Amann B, Stampfer R, Schmidt F, Mikhaiel P, Hummel B, Sterr A, Schäfer M, Grunze H. Fortschr Neurol Psychiatr. 2001 Dec; 69(12):569-80.

See reviews... See all...

Cited by 2 PubMed Central articles

Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate. [Ann Gen Hosp Psychiatry. 2004]
Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate.
Wu RH, O'Donnell T, Ulrich M, Asghar SJ, Hanstock CC, Silverstone PH. Ann Gen Hosp Psychiatry. 2004 Jul 30; 3(1):13. Epub 2004 Jul 30.
Lithium does not alter the choline/creatine ratio in the temporal lobe of human volunteers as measured by proton magnetic resonance spectroscopy. [J Psychiatry Neurosci. 1999]
Lithium does not alter the choline/creatine ratio in the temporal lobe of human volunteers as measured by proton magnetic resonance spectroscopy.
Silverstone PH, Hanstock CC, Rotzinger S. J Psychiatry Neurosci. 1999 May; 24(3):222-6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Choline in the treatment of rapid-cycling bipolar disorder: clinical and neuroch...
Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients.
Biol Psychiatry. 1996 Sep 1 ;40(5):382-8.

PubMed
[Correlation between development indices and later intelligence quotients--the f...
[Correlation between development indices and later intelligence quotients--the follow-up study of chlorinated biphenyls affected children].
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1993 Jul-Aug ;34(4):278-84.

PubMed
Differential ventricular expansion in hydrocephalus.
Differential ventricular expansion in hydrocephalus.
Eur J Pediatr Surg. 1998 Dec ;8 Suppl 1:39-42.

PubMed
Sarcoidosis of the liver and bile ducts.
Sarcoidosis of the liver and bile ducts.
Mayo Clin Proc. 1998 May ;73(5):467-72.

PubMed
Uniform requirements for manuscripts submitted to biomedical journals. Internati...
Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.
CMAJ. 1995 May 1 ;152(9):1459-73.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information