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Trends Genet. 1996 Mar;12(3):110-5.

DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale.

Author information

  • Department of Biochemistry, University of Oxford, UK. ems@bioch.ox.ac.uk

Abstract

Complete sequences of genomes and comprehensive sets of cDNA sequences open the way to a hugh range of biological problems. There is a need for analytical methods that can deal with the large number of sequences in the data banks and, ideally, we would like to analyse all sequences together. Gel-based sequencing is a serial process that analyses one sequence at a time. Oligonucleotide arrays, or 'DNA chips', are miniature, parallel analytical devices, which could bring to sequence analysis and molecular genetics many of the advantages that semiconductor devices brought to computing.

PMID:
8868349
[PubMed - indexed for MEDLINE]
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