J Pharm Sci. 1977 Jul;66(7):1047-8.

Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans.

Abstract

A method is described for the estimation of dextrorphan, a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan hydrobromide after 30 mg po, as measured by the concentration of total (free and conjugated) dextrorphan in the plasma, was determined in six human volunteers with this procedure.

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Cited by 3 PubMed Central articles

Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004. [Arch Pediatr Adolesc Med. 2006]
Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004.
Bryner JK, Wang UK, Hui JW, Bedodo M, MacDougall C, Anderson IB. Arch Pediatr Adolesc Med. 2006 Dec; 160(12):1217-22.
The effect of inhaled and oral dextromethorphan on citric acid induced cough in man. [Br J Clin Pharmacol. 1995]
The effect of inhaled and oral dextromethorphan on citric acid induced cough in man.
Grattan TJ, Marshall AE, Higgins KS, Morice AH. Br J Clin Pharmacol. 1995 Mar; 39(3):261-3.
Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver. [Br J Clin Pharmacol. 1989]
Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver.
Broly F, Libersa C, Lhermitte M, Bechtel P, Dupuis B. Br J Clin Pharmacol. 1989 Jul; 28(1):29-36.

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