In the present study, the ability of high-dose androgens, namely AAS, administered during adolescence to facilitate aggressive behavior in experimental animals was examined. Data from these studies show clearly that exposure to high doses of multiple AAS during adolescent development can predispose animals to intense bouts of aggressive behavior during young adulthood. Specifically, young adult hamsters treated with high doses of AAS throughout adolescence were more likely to attack and bite intruders placed in their home cage than sesame oil (vehicle)-treated control animals. Further, AAS-treated animals displayed a higher intensity of attack during the test period, exhibiting greater than four times the number of attacks/bites of control animals. Given the recent reports of increased incidence of AAS abuse in the adolescent population and the documented stimulatory effects of AAS on aggressive behavior, the study of the behavioral and neurobiological effects of prolonged exposure to AAS during critical phases of development such as adolescence warrants further investigation.