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Neurosci Lett. 1995 Dec 8;201(2):188-90.

Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

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  • 1Department of Medicine, Centre for Research in Neurodegenerative Diseases, University of Toronto, Canada.


The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations in familial and sporadic late-onset AD to clarify the incidence of these mutations in the disease. The current study showed lack of these mutations in 118 independent subjects affected with late-onset Alzheimer's disease.

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