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1: Curr Opin Neurol. 1995 Dec;8(6):474-9.Links

Mitochondrial defects in basal ganglia diseases.

Shoffner JM.

Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Mitochondrial DNA mutations are important causes of movement disorders and are often associated with basal ganglia degeneration. Leigh's disease and a form of generalized dystonia are caused by mitochondrial DNA mutations. Recent biochemical and genetic evidence suggests that some cases of Parkinson's disease may be caused by oxidative phosphorylation defects.

PMID: 8845935 [PubMed - indexed for MEDLINE]