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Microbiol Immunol. 1996;40(6):463-5.

Involvement of two types of TNF receptor in TNF-alpha induced neutrophil apoptosis.

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  • 1Department of Immunology and Parasitology, Yamagata University School of Medicine, Japan.


We previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) induces rapid human neutrophil apoptosis. In this paper, we examined which of the TNF receptors, p55 kDa TNF receptor (55-R) or p75 kDa TNF receptor (75-R), or both are involved in this process using specific rabbit antisera. Antibodies to 55-R (anti55-R) or 75-R (anti75-R) alone did not induce neutrophil apoptosis. Further addition of cycloheximide and anti-rabbit immunoglobulin to anti55-R but not to anti75-R accelerated apoptosis, although anti75-R augmented the capacity of anti55-R to do so. These results suggest that 55-R is a prerequisite for TNF-alpha induced neutrophil apoptosis.

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