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Ital J Neurol Sci. 1995 Dec;16(9):635-40.

Selective bilateral lesion of the globus pallidus: ten-year follow-up of memory impairment and frontal symptomatology.

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  • 1Clinica Neurologica, Universit√† di Perugia, Italy.


A case of loss of psychic self-activation (LPSA) and serious amnesia, followed for a period of ten years, is reported. MRI examination documents a selective bilateral lesion of the globus pallidus. This clinical picture, which evokes a cognitive and behavioral deficit of frontal lobe lesions, is attributed to a dysfunction of the frontal cortical area as a result of the breakdown of the frontostriatal circuits.

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