Genomics. 1996 Feb 1;31(3):395-7.

Molecular cloning of the N-terminus of GTBP.

Nicolaides NC, Palombo F, Kinzler KW, Vogelstein B, Jiricny J.

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Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.

Abstract

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

PMID:: 8838326; [PubMed - indexed for MEDLINE]

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. [Science. 1995]
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
Palombo F, Gallinari P, Iaccarino I, Lettieri T, Hughes M, D'Arrigo A, Truong O, Hsuan JJ, Jiricny J. Science. 1995 Jun 30; 268(5219):1912-4.
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Review Molecular biology of colorectal cancer.
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Cited by 5 PubMed Central articles

hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. [Genes Dev. 2001]
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.
Kleczkowska HE, Marra G, Lettieri T, Jiricny J. Genes Dev. 2001 Mar 15; 15(6):724-36.
Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. [Plant Cell. 2000]
Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA.
Culligan KM, Hays JB. Plant Cell. 2000 Jun; 12(6):991-1002.
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. [EMBO J. 1998]
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha.
Iaccarino I, Marra G, Palombo F, Jiricny J. EMBO J. 1998 May 1; 17(9):2677-86.

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Genomics. 1996 Feb 1 ;31(3):395-7.

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