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Genomics. 1996 Feb 1;31(3):395-7.

Molecular cloning of the N-terminus of GTBP.

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  • 1Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.

Abstract

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

PMID:
8838326
[PubMed - indexed for MEDLINE]
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