Abstract
Expression of murine P-glycoprotein (P-gp), encoded by mdrl or mdri3, confers a multidrug resistance phenotype. Higher expression of c-fos and c-jun has also been demonstrated in multidrug resistant human and murine cells. We detected increased expression of c-fos early in the derivation of two series of murine erythroleukemia sublines selected for resistance to vincristine or adriamycin which eventually overexpress mdr3. We speculate that early expression of c-fos prepares cells for overexpression of other genes, such as mdr3, that contribute to the multidrug resistance phenotype.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B*
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis*
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ATP-Binding Cassette Transporters / biosynthesis*
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Animals
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Blotting, Northern
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Cell Line
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Doxorubicin / toxicity*
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Drug Resistance, Multiple*
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Gene Expression
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Genes, fos
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Genes, jun
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Humans
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Leukemia, Erythroblastic, Acute
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Mice
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Proto-Oncogene Proteins c-jun / biosynthesis
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Tumor Cells, Cultured
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Vincristine / toxicity*
Substances
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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ATP-Binding Cassette Transporters
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Proto-Oncogene Proteins c-fos
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Proto-Oncogene Proteins c-jun
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Vincristine
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Doxorubicin
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multidrug resistance protein 3